While -isc- verbs aren't the majority, there isn’t a clear-cut rule to tell them apart from standard ones just by looking at the infinitive. For this reason, the most reliable way to master them is simply through practice and a bit of memorization.
The good news? The list of essential ones is actually quite manageable! Here are the most common -isc- verbs encountered in everyday conversation:
Preferire: to prefer
(Io preferisco, tu preferisci, lui / lei preferisce...)
Finire: to finish
(Io finisco, tu finisci, lui / lei finisce...)
Pulire: to clean
(Io pulisco, tu pulisci, lui / lei pulisce...)
Costruire: to build
(Io costruisco, tu costruisci, lui / lei costruisce...)
Spedire: to send
(Io spedisco, tu spedisci, lui / lei spedisce...)